Usage of this is first displayed against the Chimera Dryad, however it does not flinch. Alice can also use it against the Nabe and completely annihilate it with her sea of flames, and freely uses it when passing judgment onto the Beelzebubs as well as her ultimate battle against Luka.
During Chapter 3, while Alice is sealed in a younger body, Luka can request her to use this skill via Word of Dispel. Omega Blaze is quite effective against Mermaids, Vampires, and Plants, as they cannot withstand heat. Alice will freely use Omega Blaze during the climax of Chapter 3 when fighting alongside Luka against Seraph Eden, the final battles of Promestein and Black Alice, and Goddess Ilias.